Possible key to drug resistance in Crohn’s disease identified

Scientists have identified a normally small subset of immune cells that may play a major role in the development of Crohn’s disease generally and in disease-associated steroid resistance specifically. In a new study, they discovered that a subset of TH17 cells in humans expresses the multidrug transporter MDR1 and that these cells are linked to […]

Innate channel identified that protects against pain

Spontaneous pain of peripheral origin is pathological, and is associated with many types of disease, inflammation or damage of tissues, organs or nerves (neuropathic pain). Scientists have identified a channel present in many pain detecting sensory neurons that acts as a ‘brake’, limiting spontaneous pain. It is hoped that the new research will ultimately contribute […]

Fibromyalgia pain and fatigue reduced by vitamin D supplementation

Patients with fibromyalgia syndrome (FMS) typically have widespread chronic pain and fatigue. For those with low vitamin D levels, supplements can reduce pain and may be a cost-effective alternative or adjunct to other treatment, say researchers. In a new trial, patients with low serum calcifediol levels given Vitamin D supplementation improved significantly on a scale […]

Smart gels deliver medicine on demand

Researchers have developed a “smart” hydrogel that can deliver medicine on demand, in response to mechanical force. The researchers believe the hyaluronic acid-based hydrogels can be injected into an injury site – such as a knee or hip joint – and that as a patient walks or participates in therapeutic exercise, the walking motion will […]

Stopping liver failure from painkiller overdose

Newswise —Researchers have identified a key step for the future prevention of liver failure resulting from taking too much of the everyday painkiller paracetamol (also known as acetaminophen). They’ve discovered a channel transporting calcium across the cell membrane that is triggered by paracetamol overdose, known as TRPM2. If they can block this channel, they might […]