The Academy is pleased to provide you with access to information about the latest clinical trials in pain management.

~June 2007

New Clinical Trials June 2007
Below are abstracts of recent pain and pain management studies selected from the National Library of Medicine. Click on the link below each entry for the complete abstract.

CALIFORNIA

Nervous System Diseases (Diabetic Neuropathy)
City: La Jolla
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy California

Nervous System Diseases (Neuropathic Pain)
City: Los Angeles
Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

Nervous System Diseases (Postherpetic Neuralgia)
City: La Jolla
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

Nervous System Diseases (Postherpetic Neuralgia)
City: Loma Linda
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

Nervous System Diseases (Postherpetic Neuralgia)
City: Santa Monica
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

Spinal Stenosis
City: Escondido
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

COLORADO

Headache Disorders
City: Boulder
Purpose: If you have tried both a beta-blocker(inderal, propranolol) and an anti-epileptic (topomax, depakote)- to prevent migraines and not had good results- you may qualify for this study. We will screen you for a certain cardiac defect and if found to have this then you may be randomized to receive a remedy for the defect to potentially decrease or minimize your migraines.

Headache Disorders
City: Boulder
Purpose: A study to test two different doses of a new oral migraine prevention medicine (Lacosamide)against placebo to decrease frequency of migraines

Headache Disorders
City: Boulder
Purpose: A study to evaluate the effectiveness of three different doses of Tezampanel vs. placebo in a single episode of migraine

Nervous System Diseases (Diabetic Neuropathy)
City: Boulder
Purpose: study will test how well different doses of an investigational oral medication work compared to a placebo tablet to reduce pain caused by diabetes related nerve damage

CONNNECTICUT

Spinal Stenosis
City: New Haven
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

FLORIDA

Headache Disorders
City: Palm Beach Gardens
Purpose: To evaluate the effectiveness and safety of an investigational drug versus placebo (an inactive drug) for the prevention of migraines.

Nervous System Diseases (Diabetic Neuropathy)
City: Bradenton
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

Nervous System Diseases (Postherpetic Neuralgia)
City: Bradenton
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

Nervous System Diseases (Diabetic Neuropathy)
City: Sunrise
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

Nervous System Diseases (Neuropathic Pain)
City: Jupiter
Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

Spinal Stenosis
City: Gainsville
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

GEORGIA

Headache Disorders
City: Atlanta
Purpose: Clinical research study of an investigational oral drug compared to placebo for the treatment of a single moderate or severe headache

ILLINOIS

Migraine
City: Chicago
Purpose: To evaluate the effect of rizatriptan, alone or combined with caffeine for treating acute attacks of migraine.

INDIANA

Spinal Stenosis
City: Fort Wayne
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

LOUISIANA

Nervous System Diseases (Neuropathic Pain)
City: Covington
Purpose: Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

MARYLAND

Musculoskeletal Diseases (Bursitis)
City: Baltimore
Purpose: To study the relationship between the success of a Trochanteric Bursa injection (measured by pain relief and general patient satisfaction) and the method in which it was placed

Nervous System Diseases (Neuropathic Pain)
City: Baltimore
Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

MASSACHUSETTS

Abdominal Pain
City: Boston
Purpose: Clinical Management of Opioid-Induced Hyperalgesia with Trarmadol ER

Back Pain
City: Boston
Purpose: Clinical Management of Opioid-Induced Hyperalgesia with Trarmadol ER

Headache Disorders
City: Boston
Purpose: Clinical Management of Opioid-Induced Hyperalgesia with Trarmadol ER

Nervous System Diseases (Neuropathic Pain)
City: Boston
Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

Pelvic Pain
City: Boston
Purpose: Clinical Management of Opioid-Induced Hyperalgesia with Trarmadol ER

MICHIGAN

Migraine
City: Kalamazoo
Purpose: To determine whether C-Reactive Protein (CRP) is elevated in patients with active migraine headaches

NEW YORK

Arthritis
City: Rochester
Purpose: Testing an investigational combination of two well-known medicines for pain relief and stomach protection in one pill

Back Pain
City: Rochester
Purpose: To determine the effectiveness of Chiropractic management for treatment of chronic lower back pain in older adults

Back Pain
City: Rochester
Purpose: Testing an investigational combination of two well-known medicines for pain relief and stomach protection in one pill

Fibromyalgia
City: Rochester
Purpose: Clinical research study of an investigational medication for the treatment of Fibromyalgia

Musculoskeletal Diseases
City: Rochester
Purpose: Testing an investigational combination of two well-known medicines for pain relief and stomach protection in one pill

Nervous System Diseases (Diabetic Neuropathy)
City: Albany
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

Shoulder Pain (Arthritis)
City: New York City
Purpose: To compare the safety and effectiveness of SUPARTZ to placebo for the treatment of chronic shoulder pain.

Spinal Stenosis
City: Syracuse
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

NEBRASKA

Nervous System Diseases (Diabetic Neuropathy)
City: Omaha
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

NORTH CAROLINA

Fibromyalgia
City: Wake Forest
Purpose: Clinical research study of an investigational medication for the treatment of Fibromyalgia

Nervous System Diseases (Neuropathic Pain)
City: Winston-Salem
Purpose: To collect beginning information on whether intravenous (IV) administration of KRN5500 is safe and effective for treatment of neuropathic pain in patients with cancer.

Spinal Stenosis
City: Durham
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

OHIO

Arthritis
City: Cleveland
Purpose: Study will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

Arthritis
City: Columbus
Purpose: Study will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

PENNSYLVANIA

Nervous System Diseases (Postherpetic Neuralgia)
City: Alttona
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

SOUTH CAROLINA

Digestive System Diseases (Sphincter of Oddi Dysfunction)
City: Charleston
Purpose: This protocol is designed to explore the tolerability and efficacy of Duloxetine in the management of patients with known or suspected Sphincter of Oddi dysfunction

TENNESSEE

Arthritis
City: Nashville
Purpose: Study will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two years post reconstruction surgery, aspects of the original injury and repair, and patient characteristics are risk factors for osteoarthritis after ACL reconstruction surgery.

Spinal Stenosis
City: Bristol
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

Spinal Stenosis
City: Nashville
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

TEXAS

Nervous System Diseases (Diabetic Neuropathy)
City: San Antonio
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

Nervous System Diseases (Diabetic Neuropathy)
City: Houston
Purpose: To study the clinical effects of the investigational drug, SB-509 versus placebo in patients with diabetic neuropathy

Spinal Stenosis
City: Plano
Purpose: To assess whether the Stabilimax NZ™ is at least as safe and effective as the control therapy of fusion in patients receiving decompression surgery for the treatment of clinically symptomatic spinal stenosis at one or two contiguous vertebral levels from L1-S1.

UTAH

Nervous System Diseases (Postherpetic Neuralgia)
City: Salt Lake City
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).

WASHINGTON

Nervous System Diseases (Postherpetic Neuralgia)
City: Tacoma
Purpose: This study will test the safety and efficacy of treating Postherpetic Neuralgia patients with the analgesic patch, Bupivacaine TTS (Eladur™).


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www.aapainmanage.org